The passenger compartment of the Juke remained stable in the frontal offset test. Dummy readings indicated good protection of the knees and femurs of the driver and passenger. Nissan showed that a similar level of protection would be provided to occupants of different sizes and to those sitting in different positions. Protection of the front passenger was good for all critical body areas. In the full-width rigid barrier test, protection of all critical body regions was good or adequate for both the driver and rear passenger. In the side barrier impact, protection of all critical body areas was good and the car scored full points in this test. In the more severe side pole test, protection of the chest was rated as adequate, with good protection of other parts of the body. Tests on the front seats and head restraints demonstrated good protection against whiplash injuries in the event of a rear-end collision. A geometric assessment of the rear seats also indicated good whiplash protection. The standard-fit autonomous emergency braking (AEB) system performed well in tests of its functionality at the low speeds at which many whiplash injuries occur, with collisions avoided in most test scenarios.

In the frontal test, protection of all critical body areas was good or adequate for both dummies. In the side barrier impact, all critical body areas were well protected for both dummies and the Juke scored maximum points in this part of the assessment. The front passenger airbag can be disabled to allow a rearward-facing child restraint to be used in that seating position. Clear information is provided to the driver regarding the status of the airbag and the system was rewarded. All of the restraint types for which the Juke is designed could be properly installed and accommodated in the car.

The bonnet provided predominantly good or adequate protection to the head of a struck pedestrian, with a few poor results recorded on the stiff windscreen pillars. The bumper provided good protection to pedestrians' legs and protection of the pelvis was also good at all test locations, and the Juke scored maximum points in these tests. The Juke's AEB system can detect vulnerable road users like pedestrians and cyclists, as well as other vehicles. In tests, the system's response to cyclists was good and to pedestrians was adequate, with collisions avoided or mitigated in most cases.

The Juke has a seatbelt reminder system for the front and rear seats. The AEB system performed well in tests of its response to other vehicles at highway speeds. A lane support system helps to prevent inadvertent drifting out of lane, as well as intervening more aggressively in some critical situations. The speed assistance system uses a camera to identify local speed limits. This information is presented to the driver who can then set the speed limiter as appropriate.