The passenger compartment of the EQC remained stable in the offset frontal test. Dummy readings indicated good protection of the knees and femurs of both the the driver and passenger. Mercedes-Benz showed that a similar level of protection would be provided to occupants of different sizes and to those sitting in different positions. For the passenger, protection of all critical body areas was good. Likewise, in the full-width rigid barrier test, protection of the driver was good for all critical body parts. For the rear passenger, dummy readings of chest compression indicated a marginal level of protection for this part of the body, with good or adequate protection elsewhere. In the side barrier impact, the EQC scored maximum points with good protection all-round. Dummy readings indicated good protection for all critical body areas in the more severe side pole test, too. However, a post-test inspection revealed that the upper hinge of the rear impacted-side door had broken, and the car was penalised. Tests on the front seats and head restraints demonstrated good protection against whiplash injuries in the event of a rear-end collision. A geometric assessment of the rear seats indicated marginal whiplash protection. The standard-fit autonomous emergency braking (AEB) system performed well in tests at the low speeds at which many whiplash injuries occur, with collisions against another vehicle avoided or mitigated in all test scenarios.

In the frontal offset test, protection of all critical body regions was good for both child dummies, with the exception of the neck of the ten-year dummy where readings of neck tension indicated marginal protection. In the side barrier test, protection was good for all critical body areas for both dummies and the EQC scored maximum points in this part of the assessment. The front passenger airbag is automatically disabled when a rearward-facing child restraint is put in that seating position. Tests showed that the system worked robustly and the system was rewarded. All of the child restraint types for which the B-Class is designed could be properly installed and accommodated.

The protection provided by the bonnet to the head of a struck pedestrian was good or adequate at almost all test locations. Protection of pedestrians' legs by the bumper was good or adequate. However, protection of the pelvis was predominantly poor. The AEB system can detect vulnerable road users like pedestrians and cyclists, as well other cars. Tests of its functionality demonstrated good performance.

The AEB system performed well in tests of its response to other vehicles at highway speeds. The EQC has a seatbelt reminder system for the front and rear seats. A speed limit recognition system uses a camera and digital mapping to advise the driver of the local limit, and allows easy activation of the speed limiter. A lane support system helps the driver to avoid inadvertent drifting out of lane and also intervenes more aggressively in some certain critical situations.