The Isuzu D-MAX Crew Cab was rated by Euro NCAP in 2020.  Since then, Isuzu have improved the performance of the knee airbag and this 2022 rating combines new frontal impact tests with the results of tests done in 2020.

The passenger compartment remained stable in the offset frontal test.  Dummy readings demonstrated good protection of the knees and femurs of both the driver and passenger. This represents an improvement over the 2020 vehicle.  However, performance of the knee airbag is not symmetrical and Isuzu confirmed that poorer protection could be expected from left-hand drive vehicles (car tested was right-hand drive), although this would not affect the overall star rating.  Analysis of the deceleration of the impact trolley during the test, and analysis of the deformable barrier after the test, revealed that the D-Max Crew Cab would be an aggressive impact partner in a frontal collision, and the score was penalised accordingly.  In the full-width rigid wall test, protection of the chest of the rear passenger was rated as marginal on the basis of measurements of chest compression.  In the side barrier test, representing a collision by another vehicle, protection of all critical body areas was good for all critical body areas.  Similarly, in the more severe side pole impact, protection was good and the D-MAX scored maximum points in this part of the assessment.  In an assessment of protection in far-side impact, dummy excursion (its movement towards the other side of the vehicle) was rated as adequate.  The D-MAX is equipped with a centre airbag to protect against occupant-to-occupant interaction in side impacts.  This system worked well in Euro NCAP's test, with good protection of the head for both front seat occupants.  Tests on the front seats and head restraints demonstrated good protection against whiplash injury in the event of a rear-end collision.  A geometric assessment of the rear seats also indicated good whiplash protection.  The D-MAX is equipped as standard with a multi-collision braking system, which applies the brakes immediately after an impact to prevent the vehicle from being involved in secondary impacts.  The car also has an advanced e-Call system which, in the event of an accident, automatically sends a message to the emergency services, giving the car's location.

In both the frontal offset test and the side barrier impact, protection of both child dummies was good for all critical body areas and the D-MAX scored maximum points in this part of the assessment.  The front passenger airbag can be disabled to allow a rearward-facing child restraint to be used in that seating position.  Clear information is provided to the driver regarding the status of the airbag and the system was rewarded. With the exception of one i-Size restraint in the rear outboard seats, all of the restraints for which the D-MAX is designed could be properly installed and accommodated.

The protection provided by the bonnet to the head of a struck pedestrian, was good or adequate over almost the entire surface. The bumper provided good or adequate protection to pedestrians' legs and protection of the pelvis was also predominantly good. The D-MAX’s autonomous emergency braking (AEB) system can detect vulnerable road users like pedestrians and cyclists, as well as other vehicles. In tests, the system's response to pedestrians was adequate, with collisions avoided or mitigated in most cases, and to cyclists was marginal.  The system does not detect pedestrians to the rear of the car, and reversing tests were not performed.

Autonomous emergency braking (AEB) is fitted as standard.  The system performed well in tests of its detection and reaction to other vehicles, with impacts being avoided or mitigated in most cases.   As well as a seatbelt reminder for front and rear seats, the D-MAX has a driver monitoring system which uses steering and camera inputs to identify whether the driver is alert and focussed on the driving task or is impaired through fatigue or other factors.  The system warns the driver if impaired driving is detected.  The lane support system gently corrects the steering of the car if it is drifting out of lane and also intervenes much more aggressively in some critical situations.  The D-MAX has, as standard, a camera-based traffic sign recognition system which identifies the local speed limit, allowing the limiter to be set appropriately.