The passenger compartment of the CR-V remained stable in the frontal offset test. Dummy readings indicated good protection of the knees and femurs of the driver and passenger. Honda showed that a similar level of protection would be provided to occupants of different sizes and to those sitting in different positions. Protection of the passenger dummy was good for all critical body areas. In the full-width rigid barrier test, protection of the driver and rear passenger was good or adequate for all critical body areas. In the side barrier test, protection of all critical body areas was good and the CR-V scored maximum points. In the more severe side pole impact, dummy readings of rib deflection indicated marginal protection of the chest. Tests on the front seats and head restraints demonstrated good protection against whiplash injury in the event of a rear-end collision. However, a geometric assessment of the rear seats indicated poor whiplash protection. The standard-fit autonomous emergency braking (AEB) system performed well in tests at the low speeds, typical of city driving, at which many whiplash injuries are caused.

In the frontal offset test, dummy readings of tensile forces indicated marginal protection of the neck for the 10-year dummy. Otherwise, protection of both dummies was good or adequate. In the side barrier test, protection of both child dummies was good and maximum points were scored. The front passenger airbag can be disabled to allow a rearward-facing child restraint to be used in this seating position. Clear information is provided to the driver regarding the status of the airbag and the system was rewarded. All of the restraint types for which the CR-V is designed could be properly installed and accommodated, including in the optional third row seats.

The protection provided by the bonnet to the head of a struck pedestrian was good or adequate over most of its surface, with areas of good and poor performance. Protection of pedestrian's legs was good in all test areas and the CR-V scored maximum points. Protection of pelvis was mixed. The AEB system can detect pedestrians and cyclists, as well as other vehicles. The system performed well in pedestrian tests but was marginal in the more severe cyclist tests.

The AEB system gave generally good results in tests of its functionality at highway speeds. The car has a lane assistance system which helps prevent inadvertent drifting out of lane. A camera-based speed assistance system recognises local speed limits and presents the information to the driver, allowing the limiter to be manually set to the appropriate speed. A seatbelt reminder is standard for front and rear seats.