The passenger compartment of the 500e remained stable in the frontal offset test. Dummy numbers showed good protection of the knees and femurs of both the driver and passenger. On the driver’s side, some structures in the dashboard were considered to be potentially more aggressive if the occupants knees were to strike at a slightly different location and protection was rated as adequate. Analysis of the deceleration of the impact trolley during the test, and analysis of the deformable barrier after the test, revealed that the 500e would be a moderately benign impact partner in a frontal collision. In the full width rigid barrier test, protection of the chest of both the driver and rear passenger was rated as marginal, based on readings of chest compression.  All other critical body areas were rated as good or adequate.  In both the side barrier test and the more severe side pole impact, protection of all critical body regions was good and the 500e scored maximum points.  Limitation of occupant excursion - the extent to which the occupant is flung to the other side of the vehicle in a side impact - was rated as poor. The 500e is not equipped with a counter-measure to protect against occupant to occupant injuries in side impacts. Tests on the front seats and head restraints demonstrated good protection against whiplash injures in the event of a rear-end collision. A geometric assessment of the rear seats also indicated good whiplash protection. The 500e does not have an advanced eCall system to alert the emergency services in the event of a collision, nor a system to prevent secondary impacts.

The protection offered by the bonnet to the head of a struck pedestrian was mixed, some test points demonstrating good protection and others poor. The bumper provided good protection to pedestrian's legs at all test positions. However, protection of the pelvis was mixed, with areas of good and poor protection. The 500e's autonomous emergency braking (AEB) system detects vulnerable road users like pedestrians and cyclists, as well as other vehicles. In tests of the system's response to such road-users, performance was rated as good, with collisions avoided or mitigated in most test cases.

The 500e’s autonomous emergency braking (AEB) system performed marginally in tests of its reaction to other vehicles. A seatbelt reminder system is standard for all seats and the 500e is also equipped with ‘Drowsy Driver Alert’, which monitors the car’s path within a lane for patterns which are characteristic of a fatigued or inattentive driver. Lane assistance is provided by 'Lane Control’, a system which corrects the car's path if it is drifting out of lane and which also intervenes in some more critical situations. The speed assistance system detects the local speed limit, and allows the limiter to be set appropriately.