The passenger compartment of the GV80 remained stable in the frontal offset test. Dummy readings indicated good protection of the knees and femurs of the driver and passenger. Genesis showed that a similar level of protection would be provided to the upper legs of occupants of different sizes and to those sitting in different positions. Analysis of the deceleration of the impact trolley during the test, and of the deformation of the barrier afterwards, revealed that the GV80 would be quite an aggressive crash partner to other vehicles.  In the full width rigid barrier test, protection of both dummies was good or adequate. In both the side barrier and side pole tests, protection of all critical body areas was good and the GV80 scored maximum points. Limitation of occupant excursion - the extent to which the occupant is flung to the other side of the vehicle in a side impact - was rated as good. The GV80 is equipped with a centre airbag to protect against occupant to occupant injuries in side impacts. The airbag performed well in Euro NCAP's tests, with good protection of the dummies' heads. Tests on the front seats and head restraints demonstrated good protection against whiplash injures in the event of a rear-end collision. A geometric assessment of the rear seats indicated marginal whiplash protection. The GV80 has an advanced eCall system which automatically alerts the emergency services in the event of a collision, and multi-collision braking to prevent secondary impacts.

In the frontal offset test and the side barrier impact, protection of all critical body areas was good for both the 6 and 10 year dummies and the GV80 scored maximum points in this part of the assessment. The front passenger airbag can be switched off to allow a rearward facing child restraint to be used in that seating position. All of the child restraint types for which the GV80 is designed could be properly installed and accommodated.

The bonnet provided protection that was predominantly good or adequate over most of its surface. The bumper provided good protection to pedestrian's legs at all test positions. However, protection of the pelvis was predominantly poor. The GV80's autonomous emergency braking (AEB) system detects vulnerable road users like pedestrians and cyclists, as well as other vehicles. In tests of the system's response to pedestrians, performance was rated as adequate. The system's response to cyclists was good, with collisions being avoided or mitigated in most test scenarios.

The GV80's autonomous emergency braking (AEB) system performed well in tests of its reaction to other vehicles, with impacts avoided in almost all cases. A seatbelt reminder system is standard for all seats and the GV80 is also equipped with 'Driver Attention Warning', which monitors steering inputs for patterns which are characteristic of a fatigued or inattentive driver. Lane assistance is provided by 'Lane Keep Assist' which corrects the car's path if it is drifting out of lane and which also intervenes in some more critical situations. A speed limit information system uses a camera and digital mapping to identify local limits, allowing the driver to set the limiter appropriately.