The passenger compartment of the Octavia remained stable in the frontal offset test. Dummy readings indicated good protection of the knees and femurs of the driver and passenger. Škoda showed that a similar level of protection would be provided to occupants of different sizes and to those sitting in different positions. In the full-width rigid barrier test, protection of the chest of the rear passenger was marginal but, otherwise, protection was good or adequate for both the driver and rear passenger. In the side barrier impact, protection of all critical body areas was good and the car scored full points in this test. In the more severe side pole test, protection of the chest was rated as marginal, based on dummy readings of rib compression, with good protection of other parts of the body. Tests on the front seats and head restraints demonstrated good protection against whiplash injuries in the event of a rear-end collision. A geometric assessment of the rear seats also indicated good whiplash protection. The standard-fit autonomous emergency braking (AEB) system performed well in tests of its functionality at the low speeds at which many whiplash injuries occur.

In the frontal test, protection of all critical body areas was good for both dummies, apart from the neck of the 10 year dummy, protection of which was marginal. In the side barrier impact, all critical body areas were well protected for both dummies and the Octavia scored maximum points in this part of the assessment. The front passenger airbag can be disabled to allow a rearward-facing child restraint to be used in that seating position. Clear information is provided to the driver regarding the status of the airbag and the system was rewarded. All of the restraint types for which the Octavia is designed could be properly installed and accommodated in the car.

The bonnet provided predominantly good or adequate protection to the head of a struck pedestrian, with some poor results recorded on the stiff windscreen pillars. The bumper provided good protection to pedestrians' legs and protection of the pelvis was also generally good. The Octavia's AEB system can detect vulnerable road users like pedestrians and cyclists, as well as other vehicles. In tests, the system's response to cyclists was good and to pedestrians was adequate, with collisions avoided or mitigated in most cases.

The Octavia has a seatbelt reminder system for the front and rear seats. The AEB system performed well in tests of its response to other vehicles at highway speeds. A driver-set speed limiter helps the driver not to over-speed while a lane support system helps prevent inadvertent drifting out of lane, as well as intervening more aggressively in some critical situations.